ea0012oc22 | Pituitary, ovary and steroids | SFE2006
Matthews LC
, Spiller DG
, Rivers CA
, Norman MR
, White MRH
, Ray DW
Glucocorticoids (Gcs) are important regulators of cellular homeostasis, with their effects mediated by the intracellular glucocorticoid receptor (GR). Once activated, the GR may initiate rapid effects within the cytoplasm, but also translocate to the nucleus to affect gene transcription. The subcellular localisation of the GR is therefore an important determinant in the cellular response to Gcs.To analyse subcellular trafficking of the GR, HeLa cells wer...